CRISPR and CRISPR- associated (CAS) Genes Market Size, Share, Growth, and Industry Analysis, By Type (Genome Editing, Genetic Engineering, gRNA Database/Gene Librar, CRISPR Plasmid, Human Stem Cells, Genetically Modified Organisms/Crops, Cell Line Engineering), By Application (Biotechnology Companies, Pharmaceutical Companies, Academic Institutes and Research and Development Institutes) and Regional Forecast to 2032

Updated On: 02 September 2024

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CRISPR AND CRISPR- ASSOCIATED (CAS) GENES MARKET REPORT OVERVIEW

The Global CRISPR and CRISPR- Associated (CAS) Genes Market size was USD 44.66 million in 2023 and the market is projected to touch USD 1069.27 million by 2032, exhibiting a CAGR of 37.38% during the forecast period.

CRISPR also stands for Clustered Regularly Interspaced Short Palindromic Repeats, is a relatively new gene-editing tool that stems from bacterial immunity systems. Originally identified in 2002, CRISPR technology dramatically alters the advances in genetic engineering and further possible uses in treating diseases and improving crop yields and other industrial products. CRISPR systems are composed of two main components: Compared to the siRNA and shRNA, which are small molecules, the RNA-guided Cas proteins and the gRNA. Cas proteins, especially Cas9 protein, are endonucleases that have the ability to cleave target DNA sequences within the living organism’s genome.

COVID-19 Impact: Market Growth restrained by the Pandemic due to Shift in Research Priorities

The Global COVID-19 pandemic has been unprecedented and staggering, with the market experiencing higher-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden market growth reflected by the rise in CAGR is attributable to market’s growth and demand returning to pre-pandemic levels.

In the early stages of the COVID-19 outbreak, most research organizations and biotechnology firms re-allocated their investment and strategies towards COVID-19 solutions, vaccines, tests, and treatments. This shift meant that in the short term, funding and resources that could have been directed towards other research was directed towards COVID-19 research and or was cut off entirely for other research topics that included CRISPR-Cas technologies.

LATEST TRENDS

"Expansion into Agriculture and Food Security to Propel Market Growth"

This has shown that agriculture and food security is a growing and diversifying segment for the CRISPR and CRISPR- associated (CAS) Genes Market because of the technology’s capability for transforming crop breeding and confronting global food issues. CRISPR-Cas9 gene editing is precise and swift technique for changing genes of the plants and specific genes related to diseases resistance, tumidity, and nutrient quality, and a high yield can also be genetically altered.

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CRISPR AND CRISPR- ASSOCIATED (CAS) GENES MARKET SEGMENTATION

By Type

Based on type the market can be categorized into Genome Editing, Genetic Engineering, gRNA Database/Gene Librar, CRISPR Plasmid, Human Stem Cells, Genetically Modified Organisms/Crops, Cell Line Engineering.

• "Genome Editing"- It is worth holding that CRISPR-Cas systems are mostly regarded as tools for genome editing. Cas proteins areCas9 and Cas12 that can be engineered to cut DNA at a desired sequence in the host genome. This allows for site-specific alteration of the genome through the creation of double strand breaks (DSBs) at the locus of interest, which can result in gene disruption (k.o.), gene addition or alteration in gene activity.
• "Genetic Engineering"- Besides genome editing, it is in a broader sense of genetic engineering that CRISPR-Cas technology is employed. CRISPR-Cas systems allows researchers to modify genetic components; regulatory sequences and non-coding regions of the genome as well; to understand gene function, regulatory networks as well as epigenetic modifications.
• "GRNA Database/Gene Librar"- CRISPR-Cas systems use gRNA molecules, which is complementary to target Cas protein to certain DNA sequence. gRNA libraries and genes contain a variety of gRNA for specific genes or regions of interest or the user can design his/her own for certain genes/regions. These resources enable various large scale functional genomic and reverse genetic screens and help in tackling the gene function in different contexts.
• "CRISPR Plasmid"- CRISPR plasmids refers to recombinant vectors comprising the CRISPR-Cas which includes Cas proteins and gRNA sequences and the target cells into which the CRISPR plasmids are intended to be delivered. Plasmids are employed in a variety of experiments in laboratories where they carry CRISPR-Cas systems into the cells for the purpose of gene editing or to express CRISPR parts in the cells for further use.
• "Human Stem Cells-" CRISPR-Cas system has had an impact on the research and engineering of human stem cells and more specifically on iPSCs. Scientists employ CRISPR-Cas for deliberate genetic alterations for STEM cells with an aim of developing disease models, screening for drugs, and regenerative purposes.
• "Genetically Modified Organisms/Crops"- CRISPR Cas technology is useful in agriculture since it opens the way for creation of GMO and crop of specific required traits. By applying CRISPR-Cas, researchers get an opportunity to influence the genes in plants to increase disease resistance, increase the content of nutrients in it, predict yield, and improve the plant’s adaptation to environmental conditions; all these without making use of foreign genes featured in the traditional GMOs, which leads to regulatory issues.
• "Cell Line Engineering"- CRISPR-Cas technologies are used to create specific modifications for cell lines to be used in experiments or for production and medical treatment. Scientists can genetically alter cells or introduce fluorescent markers into the cells to watch certain cellular activities, disease pathways, and effects of drugs in Petri dishes.

By Application

Based on application the market can be categorized into Biotechnology Companies, Pharmaceutical Companies, Academic Institutes and Research and Development Institutes.

• "Biotechnology Companies"- Businesspeople apply CRISPR-Cas to create modified plants with better characteristics for growth like disease immunity, productivity, and vitamin content. This ranges from altering plants’ DNA to enable them to endure certain strains such as drought or pests, enhancing food production from farming organically.
• "Pharmaceuticals Companies"- CRISPR-Cas is used in genome editing to provide accurate positions in disease models, thus helping the drug companies in their drug development. This involves developing organism and animal models with the required gene related with the various diseases, for example cancer, genetic disorders and other diseases that cause infections.
• "Academic Institutes"- Scientists in academia apply CRISPR-Cas for studying molecular biology, genetic functions, as well as pathologies. CRISPR-Cas is used to alter the gene expression and to investigate the outcomes of gene mutations both in regular and human cell models.
• "Research and Development Institutes"- Government research facilities concerned with agriculture employ CRISPR-Cas in the create improved crop variety with the desired characteristics for food security and stability. This is regarding enhancing crop resistance to pests and diseases, diseases, drought, salinity, and other unfavorable factors, environmental conservation, and efficient use of inputs.

DRIVING FACTORS

"Advancements in Genome Editing Technology to Drive Market Advancement"

One of the key driving factors in the CRISPR and CRISPR- associated (CAS) Genes market growth is the Advancements in Genome Editing Technology. Progress made in the field of editing genes especially with the help of CRISPR and Cas genes can indeed be seen as a veritable force in the enhancement of biotechnology, medicine, agriculture and almost all sectors of life. CRISPR-Cas systems have taken place of other existing methods of genome editing because of many advantages over other techniques. These developments allow the researchers to make changes to certain genes of organisms ranging from bacteria to human beings with high accuracy and efficiency.

"Growing Demand for Personalized Medicine to Expand the Market"

Rising research on demand for precision medicine is a major trend on the CRISPR and CRISPR- associated (CAS) Genes Market. The implementation of personalized medicine is based on biosimilar principles that make treatment as effective as possible and have minimal side effects due to individual genetic characteristics. Here, CRISPR-Cas technology provides the nucleotides in the creation of the new biotechnological forefront since it offers rapid and accurate instruments for editing genomes and gene therapy. CRISPR-Cas works efficiently for alteration of required DNA components in the human body and acts as a cure or prevention for diseases which are genetically caused.

RESTRAINING FACTOR

"Off-Target Effects and Safety Concerns Poses Potential Impediments to Market Growth"

Side effects and safety issues are two major drivers of restraint in the contexts of CRISPR and Cas genes, and they limit the core developments both in the research and clinical realms of this revolutionary innovation. CRISPR-Cas systems can be very accurate in selecting the areas of DNA sequence to be modified, but it may sometimes cause unintentional modifications in other sites of the genome. Such off-target effects are dangerous because they can change genes that are necessary for proper cell operation and lead to negative outcomes including threatened genetic stability or cell toxicity.

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CRISPR AND CRISPR- ASSOCIATED (CAS) GENES MARKET REGIONAL INSIGHTS

The market is primarily segregated into Europe, Latin America, Asia Pacific, North America, and Middle East & Africa.

"North America to Dominate the Market due to Research and Development Hub"

North America has emerged as the most dominant region in the CRISPR and CRISPR- associated (CAS) Genes market share due to a convergence of factors that propel its leadership in this dynamic industry. North America and more specifically the United States of America has established a rather rich environment in terms of companies, research institutions and pharmaceutical firms investing in CRISPR-Cas research and development. It receives considerable funding and investments from the government and private entities and boasts of a favorable environment for innovation and commercialization.

KEY INDUSTRY PLAYERS

"Key Players Transforming the CRISPR and CRISPR- associated (CAS) Genes Landscape through Innovation and Global Strategy"

Major industry players are pivotal in shaping the CRISPR and CRISPR- associated (CAS) Genes market, driving change through a dual strategy of continuous innovation and a well-thought-out global presence. By consistently introducing inventive solutions and staying at the forefront of technological progress, these key players redefine the industry's standards. Simultaneously, their expansive global reach enables effective market penetration, addressing diverse needs across borders. The seamless blend of groundbreaking innovation and a strategic international footprint positions these players as not only market leaders but also as architects of transformative shifts within the dynamic domain of CRISPR and CRISPR- associated (CAS) Genes.

"List of Market Players Profiled"

• Caribou Biosciences (S.)
• GE Healthcare Dharmacon(S.)
• Addgene(S.)
• Takara Bio USA(S.)
• Horizon Discovery Group(U.K.)

INDUSTRIAL DEVELOPMENT

"Dec 2020": Intellia Therapeutics, Inc. has provided preclinical data of NTLA-5001, Intellia Therapeutics The wholly-owned Wilms ‘Tumor 1-directed TCR-T cell therapy candidate acute myeloid leukemia.

REPORT COVERAGE

The study encompasses a comprehensive SWOT analysis and provides insights into future developments within the market. It examines various factors that contribute to the growth of the market, exploring a wide range of market categories and potential applications that may impact its trajectory in the coming years. The analysis takes into account both current trends and historical turning points, providing a holistic understanding of the market's components and identifying potential areas for growth.

The research report delves into market segmentation, utilizing both qualitative and quantitative research methods to provide a thorough analysis. It also evaluates the impact of financial and strategic perspectives on the market. Furthermore, the report presents national and regional assessments, considering the dominant forces of supply and demand that influence market growth. The competitive landscape is meticulously detailed, including market shares of significant competitors. The report incorporates novel research methodologies and player strategies tailored for the anticipated time frame. Overall, it offers valuable and comprehensive insights into the market dynamics in a formal and easily understandable manner.